4/11/2023 0 Comments Rhesus mokey![]() Recent studies have shown that rhesus macaques 11, 12 and cynomolgus macaques 13 can be infected by SARS-CoV-2 and the disease course resembles some features of human COVID-19 infection. ![]() For SARS-CoV-1, though rhesus macaques became the preferred species, yet the literature suggests there is no significant difference in susceptibility of cynomolgus ( Macaca fascicularis) or rhesus macaques ( Macaca mulatta) to infection, virus replication and pathology 7, 8, 9, 10. Prior NHP models developed for SARS-CoV-1 and MERS have shown respiratory induced pathology with similar features as those seen in humans, including diffuse alveolar damage. Due to their obvious physiological similarities to humans, non-human primates (NHPs), such as macaques, have long been recognised as the most clinically relevant animal for the development of in vivo models of human disease. The development of animal models that replicate human disease is a crucial step in the study of pathogenesis and transmission, in addition to the assessment of the safety and efficacy of candidate vaccines and therapeutics. Among the clinical and pathological signs of SARS-CoV-2 infection in humans, pneumonia accompanied by respiratory distress seem to be the most clinically relevant 5, 6. It has currently infected >57 million individuals resulting in >1.3 million deaths 4. The genetic sequence of the causative agent was found to have similarity with two highly pathogenic respiratory beta Coronaviruses, SARS-CoV-1 1 and MERS 2, and was later called SARS-CoV-2 3. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.Ī novel acute respiratory syndrome, now called Coronavirus disease-19 (COVID-19) was first reported in China in December 2019. In contrast to prior publications, in which rhesus are accepted to be the preferred study species, we provide convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human population and both species should be used to evaluate the safety and efficacy of interventions against SARS-CoV-2. ![]() We describe a new method for lung histopathology scoring that will provide a metric to enable clearer decision making for this key endpoint. This finding is reiterated by our transcriptional analysis of respiratory samples revealing the global response to infection. Immune responses against SARS-CoV-2 are also similar in both species and equivalent to those reported in milder infections and convalescent human patients. ![]() Here, we show that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to assess the safety and efficacy of novel vaccines and therapeutics. Nature Communications volume 12, Article number: 1260 ( 2021)Ī novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
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